Chronic Lower Back Pain Market Size, Share, Trends and Forecast, 2030

DelveInsight’s ‘Chronic Lower Back Pain (CLBP) Market Insights, Epidemiology and Market Forecast–2030’ report delivers an in-depth understanding of the Chronic lower back pain (CLBP), historical and forecasted epidemiology as well as the Chronic lower back pain (CLBP) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

Chronic Lower Back Pain (CLBP) Disease Understanding and Treatment Algorithm

Chronic Low Back Pain (CLBP) Overview

Chronic low back pain (CLBP) is defined as pain that persists for 12 weeks or longer, even after an initial injury or underlying cause of acute low back pain. Low back pain is very common and at one point everyone must have faced this problem. Lower back pain that is long-term (for more than 3 months) is called chronic low back pain, this condition might originate from an injury, disease, or stress on different structures of the body, and pain may vary significantly and maybe felt as bone pain, nerve pain, or muscle pain. The intensity of the pain also ranges from mild to severe. CLBP is the second leading cause of disability worldwide being major welfare and economic problem. The prevalence of CLBP in adults has increased significantly in the last decade and is continuously increasing vividly in the aging population. This condition affects men and women in all ethnic groups equally. This disease also leads to stress, depression, and anxiety. CLBP affects physically and psychologically and creates a significant amount of economic burden due to loss of function, loss of work productivity, treatment costs, and disability payments.

The probable causes of CLBP are the curve of the spine, such as scoliosis or kyphosis, medical problems (fibromyalgia or rheumatoid arthritis), and piriformis syndrome (a pain disorder involving a muscle in the buttocks called the piriformis muscle). Many people with CLBP have arthritis or tear of the spine due to heavy exercise, herniated disk, or due to surgery. A herniated disc is the part of the spinal disk pushed onto the nearby nerve. Usually, these disks provide space and cushion in the spine and the loss of movement can be seen as overtime if these disks dry out and become thinner and brittle. Spinal Stenosis is the condition that arises if the spaces between the spinal nerves and spinal cord become more narrowed.

Chronic Low Back Pain (CLBP) Diagnosis

The diagnosis and evaluation of CLBP are very important to reduce or to rule out the risk factors due to severe injury. The first recommendation is a thorough physical examination by a well-trained physician. CLBP testing may include blood tests, radiography (X-ray imaging), bone scans, computed tomography (CT) scans, magnetic resonance imaging (MRI), diagnostic injections, bone scan, electromyography (EMG), lumbar radiography, and many other specialized tests.

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Chronic Low Back Pain (CLBP) Treatment

CLBP is the most prevalent chronic pain condition and the second most common cause of disability in the US, after arthritis or rheumatism. CLBP may be nociceptive or neuropathic or include both components. The presence of a neuropathic component is related to the more intense pain of longer duration, and a higher prevalence of co-morbidities. The actual mechanism and cause of CLBP are still unknown and due to this situation, there are no universally accepted treatment guidelines and the management of the treatment is limited. If the source of the pain is not known or can not be treated, the best option remains is to reduce the flare-ups and making the pain manageable with nonsurgical treatments. There are non-surgical treatments (physical therapy, diet, meditation, lifestyle modifications) Injection-based Treatments, pharmacologic treatments.

For some patients, CLBP can be relieved by single-agent therapy, but as both nociceptive and neuropathic mechanisms are often present, combining agents with different mechanisms of action is a rational approach Analgesics, anti-inflammatory drugs, muscle relaxants, and other medications can be used to help control chronic back pain. However, most come with unwanted side effects and are not intended for prolonged use. Opioid medication should not be used without a physician’s recommendation.

The use of non-opioid analgesics such as acetaminophen (APAP), non-steroidal anti-inflammatory drugs (NSAIDs), or cyclooxygenase-2 (COX-2) inhibitors for initial management for LBP. The use of muscle relaxants should be avoided in patients with CLBP. Treatment of mild CLBP often begins with the use of NSAIDs and mild non-opioid analgesics, while more potent opioid analgesics are reserved for the pain of moderate-to-severe intensity.

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Chronic Low Back Pain (CLBP) Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Population of Chronic Lower Back Pain, Total Diagnosed Prevalent Population of Chronic Lower Back Pain, Gender- Specific Diagnosed Prevalence of Chronic Lower Back Pain, Age - Specific Diagnosed Prevalence of Chronic Lower Back Pain, Severity Specific Diagnosed Prevalence of Chronic Lower Back Pain, Number of CLBP Patients on Prescription Medications by different Class and Number of CLBP Patients on Opioids by low dose, high dose and Overdose scenario of CLBP in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2017 to 2030.

Key Findings

· This section provides glimpses of the Chronic low back pain (CLBP) epidemiology in the 7MM.

· As per DelveInsight’s analysis, the total Prevalent Population of Chronic low back pain (CLBP) in the 7MM was found to be 73,802,461 in 2017.

· The estimates show higher prevalence of Chronic low back pain (CLBP) in the United States with 33,821,043 cases in 2017.

· Amongs EU5, United Kingdom show higher prevalence of Chronic low back pain (CLBP) followed by Germany and France, Italy and Spain respectively.

· As per DelveInsight’s analysis, a higher percentage of diagnosed prevalence was observed for females, in comparison to males, in all the 7MM countries, except Japan, wherein males occupy a larger patient pool than females

· Among the EU5 countries, United Kingdom had the highest diagnosed prevalent population of CLBP with 3,517,443 cases, followed by Germany and the France. On the other hand, Spain had the lowest diagnosed prevalent population.

Country-wise Chronic low back pain (CLBP) Epidemiology

The epidemiology segment also provides the Chronic low back pain (CLBP) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Chronic Low Back Pain (CLBP) Drug Chapters

The drug chapter segment of the Chronic low back pain (CLBP) report encloses the detailed analysis of CLBP marketed drugs, mid phase and late stage (phase III) pipeline drugs. It also helps to understand the Chronic low back pain (CLBP) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.

Chronic Low Back Pain (CLBP) Marketed Drugs

1. Cymbalta: Eli Lilly and Company

Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) developed by Eli Lilly and Company. Serotonin and norepinephrine hormones present in the brain and spinal cord and are believed mediate core mood symptoms and help regulate the perception of pain. Duloxetine hydrochloride is the active ingredient of this medication. The drug is believed to be related to an increase in the action of serotonin and norepinephrine in the brain and spinal cord. People who suffer from CLBP experiences various range of pain and often struggle to find the right medication. The drug is been approved for the management of various other indication like Neuropathic Pain, Osteoarthritis, Generalized Anxiety Disorder, Major Depressive Disorder, Fibromyalgia, Diabetic Kidney Disease, etc.